Roche has appointed Pamela Carroll as its new Global Head of Pathways Biology within in Pharmaceutical Research and Early Development unit.

She will also act as oncology discovery site head at the company’s research facility in Nutley, New Jersey.

Mike Burgess, Global Head Oncology, Discovery and Translational Area, and head, large molecule research at Roche, says Pam “has built a reputation for scientific excellence and leadership in the field”.

She first entered the pharmaceutical industry in 1999 with Bristol-Myers Squibb before joining Merck. Two years ago, she moved to the Belfer Institute of Applied Cancer Sciences at Dana Farber Cancer Institute, Harvard Medical School.

“Her broad knowledge and successful history in leading oncology drug discovery efforts make her is an ideal fit for this position,” Mr Burgess added.

The NHS faces financial risks and worries over organisational success due to the lack of female leaders on Clinical Commissioning Groups, a new report has warned.

Releasing Potential: Women doctors and clinical leadership found women had experienced difficulties joining CCG leadership committees despite evidence showing gender diverse boards improve financial performance.

GP Penny Newman, report author, says the lack of diversity presents “a risk to developing the collaborative and inclusive leadership behaviour needed for organisations to succeed in a complex system”.

The report, funded by the National Leadership Council, was based on in-depth interviews with 26 leading female GPs and consultants with the outcomes tested on a further National Leadership Council workshop which included 43 female medical leaders and other experts.

Several interviewees said they had signalled an intention to take a senior role within CCGs but had experienced issues in joining. Previously, claims had been made of a ‘jobs for boys’ culture from female GPs following a similar study by Pulse. One interviewee even described one leadership committee as consisting of “clubs, gangs and mafia”, insisting there was “exclusion, inequity and disengagement of the rest of the profession”.

Research from the report said that female GPs were more likely to work with marginalised and vulnerable communities and were found to have qualities such as empathy, being able to question and admit vulnerability and offering support and development to others.

“While the number of female doctors continues to rise, there remains an unacceptably small proportion in leadership positions within the NHS,” said Dr Newman.

“Female doctors represent a valuable resource to the health service, both in terms of the style of working and individual talent.

“The NHS needs to enable them to achieve leadership positions through more flexible working and other initiatives to maximise the potential of the workforce and ultimately provide a better service for patients.”

The report follows an investigation by HSJ which revealed that 85% of CCGs were led by men.

Novartis has appointed Dr Timothy Wright as its new Global Head of Development.

Dr Wright joined the pharmaceutical company in 2004 and most recently served as Senior Vice President and Global Head of Translational Sciences at Novartis Institutes for BioMedical Research (NIBR).

His previous positions include exploratory therapy area leader for Inflammation at Pfizer and chief of the Division of Rheumatology and Clinical Immunology at the University of Pittsburgh.

Sanofi plans to cut hundreds of jobs in its sales and R&D departments in the US over the coming months.

The job losses come as the company prepares to lose patent exclusivity on key products and fully absorbs Genzyme following its acquisition in February 2011.

The sales jobs cuts would be focused on Sanofi’s cardiovascular and oncology groups, aiming for cost savings of $2.9 billion per year, said CEO Christopher Viehbacher.

More than 9,000 jobs have been cut at the company over the last several years, including approximately 3,800 sales employees in the US.

The staff reductions in mature markets have been similar at many other pharmaceutical companies, adding vacancies in emerging markets.

According to Mr Viehbacher, Sanofi has added more than 3,700 pharmaceutical jobs in emerging markets since 2008.

Sanofi is expected to overthrow Pfizer’s nine-year reign as the world’s biggest drug maker, according to new research.

The French pharmaceutical company is expected to retain the top spot until at least 2016, with Pfizer falling to third place behind Novartis due to the loss of Lipitor’s US patent protection, according to EvaluatePharma (see figure one).

The report says that Sanofi’s numerous acquisitions over the last decade have contributed largely to the company’s success, gaining $20 billion after it bought out Genzyme.

Sanofi’s mergers over the last decade have contributed a great deal to its current position, starting with its $30 billion deal with Synthélabo in 1999.

It is expected that the company will retain its top position until at least 2016, mainly thanks to sales of enzyme replacement therapies through its acquisition of Genzyme.

Also, the company’s addition of Cerezyme and Myozyme blockbuster drugs will help fill the gap left by Lovenox, Taxotere, and Plavix, which loses US patent protection in 2012.

Pfizer’s $68 billion buyout of Wyeth in 2009 helped fill the gap left by Lipitor, but it will be difficult to replace the drug’s global sales figure of $13.4 billion seen in 2008, which set the record as the biggest selling medicine.

Following its loss of US patent protection in November 2011, Lipitor sales are estimated to shrink to $2 billion by 2016.

However, pipeline products such as rheumatoid arthritis (RA) pills tofacitinib and Eliquis are expected to boost Pfizer’s drug sales after 2016, which will help retain the company’s position in the top-five pharmaceutical companies.

Merck’s four-year outlook is seen as bleak despite its takeover of Schering-Plough for $41 billion in 2009, with only 1% annual sales growth predicted, conceding to European companies GlaxoSmithKline and Roche to overtake the company.

EvaluatePharma predicts that Johnson & Johnson’s recent pipeline successes will benefit the company in the coming years, despite its drugs arm being substantially smaller than the five biggest pharma companies.

It is thought that Novartis will be Sanofi’s closest competition over the next few years, with strong sales growth from Gilenya and Tasigna due to Diovan’s loss of patent protection next year.

Figure 1:

Lundbeck has appointed Jens Peter Balling and Iman Barilero as vice presidents in its R&D organisation.

The new appointments follow Lundbeck’s recent consolidation of its R&D activities into one organisation, creating a new unit.

Peter Balling (pictured, right) has been appointed as Vice President of the new unit, which will focus on regulatory product support, patient safety and quality assurance of clinical research.

Barilero (pictured, below) will be responsible for increasing Lundbeck's strategic efforts to build and maintain constructive cooperation and dialogue with national and international regulatory authorities.

Anders Gersel Pedersen, Executive Vice President of R&D at Lundbeck, said: “The regulatory and safety areas are an increasingly important prerequisite for this. The creation of one new unit and the increased focus on the other gives us a strong position in these areas.”

Peter Balling joined Lundbeck in 2006 as divisional director of global pharmacovigilance, previously working at Novo Nordisk and Nycomed.

Barilero began work for Lundbeck in 2007, when she served divisional director of regulatory development, strategy and policy, with previous experience at Hoffmann-La Roche and Johnson & Johnson.

Search for careers at Lundbeck.

Boehringer Ingelheim is to work with Pantheon to develop two projects worth over $18 million involving combination drugs to treat type II diabetes.

Mark Kontny, Chief Scientific Officer at Pantheon, said: “I am very gratified that Boehringer Ingelheim recognises our expertise in formulating, scaling and successfully launching complex formulations such as these molecules. It is this kind of support and recognition that has enabled us to develop our market leading position in pharmaceutical development services.”

The projects are set to span over a three year period.

Patheon is a global provider of pharmaceutical services, manufacturing at ten facilities and nine development centres across North America and Europe.

Nycomed, a Takeda company, has appointed Jostein Davidsen as its new Head of Emerging Markets.

Mr Davidsen will take on the post in addition to his current role as Area Head of Russia/CIS, reporting to Frank Morich, EVP, International Operations at Takeda Pharmaceuticals International, and CEO of Nycomed.

“Jostein's strong track record of leading Russia/CIS over the past 17 years makes him an ideal candidate for this position,” said Mr Morich.

“His extensive knowledge of the industry, combined with vision and tenacity, has propelled Russia/CIS to become one of Nycomed's top revenue contributors.”

Takeda’s acquisition of Nycomed in September 2011 was driven by Nycomed’s presence in Emerging Markets in Russia/CIS, Latin America, Middle East-Turkey-Africa and South Asia.

Takeda is a research-based global company with a main focus on pharmaceuticals. The combined company has an active commercial presence in the therapeutic areas of metabolic diseases, gastroenterology, oncology, cardiovascular health, CNS diseases, inflammatory and immune disorders, respiratory diseases and pain management.

Roche has appointed Dr Harsukh Parmar as Head of Translational and Experimental Medicine (TM) of its Inflammation Discovery and Translational Area (DTA).

Dr Parmar will be responsible for the strategy and implementation of early clinical progress in Inflammation as well as collaborating with Discovery and Clinical Development to ensure high quality of compounds used throughout drug production.

Dr Jacques Banchereau, Head of the Inflammation and Virology Discovery and Translational Areas, said that Harsukh is recognised as “an expert in respiratory, inflammation, immunology and oncology, and possesses the right combination of experience for this pivotal position”.

Dr Parmar joins Roche from AstraZeneca in the UK, where he worked as Early Development Director, Vice President and Global Head of Early Clinical Development in the Respiratory and Inflammation Therapeutic Area. He also previously served at Roche as Global Clinical Science Leader and Director in Oncology, Immunology, Virology and Transplantation.

“Having previously worked for Roche and recognising the rich heritage of innovation that has come from the pharma business in small molecules and biologics, I was excited to rejoin a company that has been a leader in many of its respective fields,” said Dr Parmar.

Are you lacking motivation and confidence at work? Do you feel anxious about the security of your job? As employment statistics continue to deteriorate, we could put these feelings down to the saddening status of the economy, but is that really a good enough excuse to work in a job you don’t enjoy?

Don’t get me wrong, we should always feel grateful for our job, especially in the current climate. But our jobs are what make us get up in the mornings. So, shouldn’t we make the most of our 40+ hours a week?

In any case, if you’re feeling down in the dumps at the moment and have realised that it’s not the economy, but actually, you’re not enjoying your job, it could be time for a change of scene.

Ask yourself these questions:

• How long have you be in your current job?
• Has your salary increased since your last job?
• Are your responsibilities at work increasing or decreasing?
• Are you involved in important decision making at work?
• Do you feel challenged by your role?
• Are you just hopping from one employer to the next staying in the same position?
• Have people hired after you been promoted faster?
• Do your colleagues seek out work advice from you?
• Do you dread going to work?

It’s pretty obviously which of these answers are good and which are bad signs of what you should do next.

It may be a case of considering other roles, as it’s true what they say: It’s much easier to find a job if you have a job. In which case, give an honest analysis of your career as it stands and assess your long-term objectives. Are you doing what you always wanted to? Is your current job a step in the right direction?

If not, or you can think of something better and more relevant to your personal career goals, no time like the present to sort yourself out. It’s only too easy to become too comfortable with your job and falling into a career slump.

But, it could also mean that you should think about discussing your feelings with your boss. Ask how you can contribute more to the company, and use your initiative to put forward some ideas to keep things fresh and involving. You’re more likely to enjoy your work if you’re doing different things and being recognised for your efforts.

A career rut is never easy and new opportunities can often feel out of sight. But if you’re feeling unmotivated and lacking stimulation in your job, it’s worth having a serious think about what you should really do.

Visit PharmaJobs for the latest vacancies in pharmaceutical sales.