Bristol-Myers Squibb has announced the launch of Daklinza®▼ (daclatasvir) in the UK, offering a new treatment combination for chronic hepatitis C shown to provide cure in a high number of patients.
Daclatasvir is an oral, once-a-day pill, used in combination with other medicinal products, to treat adult patients with chronic hepatitis C. In combination with other agents it works across multiple hepatitis C genotypes.
In 2014, the New England Journal of Medicine (NEJM) reported that daclatasvir (the first NS5A inhibitor to be licensed in Europe), used in combination with sofosbuvir, offered clinical cure rates of 98% and 89% in patients with hepatitis C genotype 1 and 3 respectively. Daclatasvir has also shown, in a separate study, to provide clinical cure rates in hepatitis C genotype 4 of up to 100% when combined with peginterferon alfa and ribavirin.
Daclatasvir offers the option of a curative oral regimen that does not require interferon2, commonly associated with sustained flu-like side effects, for around 90% of cases in the UK.
Charles Gore, Chief Executive of The Hepatitis C Trust, said: “We are delighted by today’s announcement. Each new treatment for hepatitis C takes us closer to making the elimination of hepatitis C a realistic possibility, by improving both cure rates and tolerability.”
In January 2014, daclatasvir was brought forward for priority review by the European Medicines Agency (EMA), recognising the unmet need that exists in the hepatitis C patient population.
“We are committed to improving the quality of life of patients living with hepatitis C and paving the way to cure this chronic and devastating condition,” said Johanna Mercier, General Manager, Bristol-Myers Squibb, UK and Ireland.